Stef Foster and Lena Adams, a lesbian couple, have a family of adopted, biological, and foster children. Mariana and Jesus are adopted 15-year-old twins and Brandon is Stef's 16-year-old biological son from a previous marriage. Everything is going fine in the house until Callie and Jude arrive. 16-year-old Callie and her 12-year-old brother Jude have been in many different foster homes, but when they are placed with the Fosters, things begin to happen. In this series, the Fosters will deal with many different issues: hook-ups, break-ups, romances, and important life lessons.
Callie meets the Foster Family, Stef the police officer, her life partner Lena the Vice Principal, Stef Biological son Brandon for previous marriage with Mike also police officer, Twins adopted by Stef and Lena Jesus and Marianna. Just released from Juvie, Callie tries to get to her brother Jude who is still in a home with a foster father, who was abusive. Stef tells Lena they cannot take in another child, otherwise the place is going to be like the Brady Bunch and they are not the Brady Bunch. Callie catches Marianna taking Jesus ADHD medication and they are not off to a good start. After Stef meets Jude, she tells Lena they will find room for them. Written by RG
Callie and Jude are staying with the Fosters, Stef talks to Brandon about run off with Callie to get her brother Jude, because the step father had a gun and that decision not to call her could have been deadly, but her and Lena decided he has learn from the experience and does not need to be punished. Meanwhile Jesus is concerned about Marianna he discovered she is taking his medication and selling it at school, and given the money to their birth mom who is a drug addict. Lena who is the Vice Principal is informed drugs is in the school, she catches a student and they accuse Callie. Stef and Lena do not believe Callie when she tells them she is not involved. Marianna goes to confess and Jesus takes the fall for her. Written by RG
A stern foster-care worker supervises Callie. Brandon searches for Callie after he confesses why she ran away; Mariana gets involved with the school play; and Jesus struggles with his new medication and tries out for the wrestling team.