Queen of the South tells the powerful story of Teresa Mendoza, a woman who is forced to run and seek refuge in America after her drug-dealing boyfriend is unexpectedly murdered in Mexico. In the process, she teams up with an unlikely figure from her past to bring down the leader of the very drug trafficking ring that has her on the run.
Teresa, now in Texas, must prove herself to Camila and do a risky job for her. Epifanio contacts his wife on finding Teresa, unaware she has her. Brenda and her son continue to evade the Cartel and receive a helping hand.
Teresa's first solo drug run takes a drastic turn. Brenda and her son arrive in Dallas. Epifanio believes Camela may be hiding Teresa, and sends Cesar to snatch her. Camela seeks to bring her empire to Mexico.
Teresa and James infiltrate a high end party for a wetwork job. Brenda works with a drug dealer in order for her and Tony to survive. Epifanio looks to break Camila's ties with the Colombians.
Camila, in dire need of product because of Epifanio's betrayal, sends Teresa and James on a critical drug run that ends up in disaster. Riddled with debt and short on supply, Camila grows desperate and considers giving Teresa up. Meanwhile, Brenda's burgeoning drug enterprise creates a rift between her and Tony.
Teresa's desire to escape grows with an opportunity to obtain papers. Desperate for product as The Birdman encroaches further on her territory, Camila, taps into her last cash reserves to make a critical drug buy and sends Teresa and James out on a midnight mission to deliver 5 million in cash.
Camila, out of money, cocaine and options, decides to take an incredibly risky step by ripping off some dangerous dealers out of Florida. In order to pull this off, Teresa must go undercover. With her life on the line, she's forced to make a choice that will forever change her. Meanwhile, Brenda's supplies are low, and she makes a shift to a much more addictive and dangerous product.
Camila returns to Mexico at Epifanio's request. Teresa is able to sneak Maria and Angel back to Mexico and must deal with problems from those who oppose the cartel. James continues his hunt for Teresa.